Description
MonolixSuite™ Autumn School: Advanced Modeling in Pharmacometrics
Beyond Routine Workflows: Expand Your Skills in Advanced Modeling, Automation and Reporting
Free Online Training | October 27 - 31, 2025
Why This Training Matters
The MonolixSuite™ Advanced Autumn School is designed for pharmacometricians who already know Monolix basics and want to go further. Over five intensive sessions you'll learn how to handle complex PK/PD and develop QSP models, work confidently with non-continuous data, and automate your workflows to save time and reduce errors. More then a software tutorial, this course gives you the framework, skills and mindset to turn routine analyses into insights that support dose selection, trial designs and regulatory decisions.
You'll see not only "how" to use advanced Monolix features but "why" certain approaches work, and how to apply them to real-world challenges. With hands-on exercises, live expert guidance, and a free temporary MonolixSuite™ license, you'll be able to experiment directly on your own projects and bring back immediately usable workflows to your team.
How You Will Learn
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Five Live online lectures led by MonolixSuite™ experts each day
Learn directly from the people who develop and use the tools at the highest level, gaining not just instructions but insight into best practices, strategies, and real-world applications. -
Two identical 1.5 h sessions per day - choose the time zone that fits you - and video recordings
Ensure you can participate live, ask questions, and learn at your best time without missing content or interaction. -
Interactive Q&A chat during each session with MonolixSuite™ experts
Get immediate answers to your modeling challenges and clarify concepts as you learn, turning lectures into active problem-solving sessions. -
Hands-on exercises to reinforce new skills
Apply what you've just learned in a guided environment, moving from theory to practice and cementing your ability to replicate these workflows later. -
Comprehensive materials: presentations, datasets, Monolix projects, and video recordings
Build your own reference library to revisit concepts, test workflows on your own time, and accelerate mastery after the course. -
Certificate of attendance
Demonstrate your training in advanced pharmacometrics and MonolixSuite to colleagues, supervisors, or regulatory bodies.
Free temporary license for all MonolixSuite™ applications
Use the same tools you're learning on your own projects, experiment with advanced features, and get immediate help from experts during the course - turning learning into direct project impact.
Skills and Insights You'll Gain
Session 1: Building the Skills for Advanced PK/PD: Model Selection, Diagnostics and Strategy
In this first session, you'll move beyond routine PK/PD workflows and learn to think like an advanced modeler. Through a step-by-step complex case study, you'll practice selecting the right models, apply diagnostic and visualization tools effectively, and perform sensitivity analyses to ensure predictive accuracy. By the end, you'll be able to confidently tackle challenging PK/PD datasets, and extract reliable insights that support model development decisions.
Session 2: Inside the Calculation Engine: Understanding and Controlling Monolix Algorithms
Monolix has as an easy-to-use interface, but behind every click are powerful algorithms that shape your results. In this session, you'll uncover how these methods work, how their settings influence outcomes, and why understanding them is essential for creliable, efficient modeling. By the end, you'll be able to choose and adjust algorithms with confidence, defend your modeling decisions to colleagues and regulators, and extract more reliable insights from your analyses.
Session 3: Beyond Continuous Outcomes: Modeling Time-to-Event, Count and Categorical Data in Monolix
Continuous outcomes are only part of the story - data in drug development comes also as time-to-event, counts, or categories. In this session, you'll learn how Monolix handles these non-continuous data types, from dataset structure and dedicated diagnostic plots to model coding in Mlxtran. Using real case studies, you'll practice building and interpreting survival, count, and categorical models, including covariate effects and event probability predictions.
Session 4: Turning Repetition into Strategy: Automation and Standardization of Workflows in R
Monolix's graphical interface is ideal for exploring and developing models, but it also means repeating the same clicks across projects. Few users realize how much can be automated to create reproducible, transferable workflows, reduce errors, and accelerate analyses. In this session, you'll learn to streamline your work with plots presets, lixoftConnectors in R, and integrated report generation. We'll show how to create, share and apply custom plot settings, script Monolix and Simulx workflows in R, and generate both exploratory and regulatory-style reports using Quarto. By the end, you'll know how to turn automation into a strategic advantage rather than a routine technical task.
Session 5: From PK/PD to Systems Thinking: Applying QSP Modeling in Monolix
While PK/PD and QSP models both use ODEs, QSP goes further by linking biological pathways, mechanisms and diverse data sources to address system-level questions beyond the scope of standard PK/PD. In this session, we'll walk through the development and calibration of a full QSP model using a real FAAH inhibitor example. You'll see how in vitro, preclinical, and clinical data come together into a single mechanistic framework, how model equations are formulated, and how sensitivity and uncertainty analyses reveal influential parameters and test key assumptions. By the end, you'll understand the principles and workflow of QSP modeling in Monolix, see how it connects to traditional PK/PD approaches, and gain the insight needed to start applying these methods in your own projects or collaborations.
Objectives
Session 1: Building the Skills for Advanced PK/PD: Model Selection, Diagnostics and Strategy
Learn to move beyond routine workflows and confidently build, diagnose, and refine advanced PK/PD models that support critical development decisions.
Session 2: Inside the Calculation Engine: Understanding and Controlling Monolix Algorithms
Gain the insight to understand, adjust, and defend the algorithms behind Monolix so your results are credible, efficient, and regulator-ready.
Session 3: Beyond Continuous Outcomes: Modeling Time-to-Event, Count and Categorical Data in Monolix
Master the structure and modeling of time-to-event, count, and categorical data to expand your analyses beyond standard PK/PD outcomes.
Session 4: Turning Repetition into Strategy: Automation and Standardization of Workflows
Discover how to automate, standardize, and share Monolix workflows so you can reduce errors, save time, and deliver consistent results across projects.
Session 5: From PK/PD to Systems Thinking: Applying QSP Modeling in Monolix
See step by step how QSP modeling integrates diverse data and mechanisms in Monolix to tackle system-level questions and guide real decisions.
Certificate
By completing/passing this course, you will attain the certificate - MX Attendance
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