From Simple to Complex Simulations in Pharmacometrics using Simulx Confidently design and analyse simulations in pharmacometrics to improve MIDD decision making. Weather you’re looking to explore PKPD models, compare dosing regimens or optimize next phase of a clinical trial, this hands-on course will guide you step by step through the entire process – from basic simulations to advanced, real-world applications. Why take this course? Simulations are a cornerstone of pharmacometrics, allowing researchers and modelers to explore drug behaviour, optimize study designs, and assess clinical strategies before trials even begin. This course offers:   Step-by-step guidance on Simulx, a powerful simulation tool of the MonolixSuite Practical knowledge on building and interpreting simulations Exposure to various case studies used in drug development Expert lectures with hands-on exercises Live Q&A with discussion forums to get direct feedback   Who should attend? This course is designed for pharmacometricians and modelers, researchers and scientists in drug development, regulatory professionals, students and academics. Anyone looking to improve their simulation skills – no prior Monolix or Simulx experience is required! What the course offers Training over 5 days: One lecture per day Live sessions at 9 AM &5 PM (CET) to accommodate global participation Hands-on exercises, lecture materials and video recordings Live Q&A sessions with experts and discussion forum Temporary MonolixSuite licence to practice during and after the course   Agenda Day 1 – Foundations of Simulations in Simulx How to import a Monolix project for simulations. Understanding imported elements (parameters, covariates, treatments, etc.). Setting up a simulation scenario and exploring dosing regimens. Analyzing results and visualization options. After this session you’ll be able to create your own simulation scenarios and use Simulx for both exploratory analysis and full scale simulation. Day 2 – Advancing Beyond Single Simulations Creating simulation groups. Post-processing outputs into outcomes and endpoints. Using statistical tests for group comparisons. Running replicates and incorporating uncertainty.  You’ll move beyond basic simulation to conduct robust comparison of dosing regimens, populations and sample sizes. Day 3 – Exposure Metrics and Exposure-Response (E-R) Analysis Definition of exposure metrics. Calculating exposures in a single and multiple intervals. E-R simulations for continuous and non-continuous endpoints. At this session you’ll learn to perform E-R simulations and apply them to real world decision-making. Day 4 – Creating Simulations from Scratch Writing models in Mlxtran. Defining more complex model elements. Translating models for simulations from scientific publications. This session will show that Simulx is a powerful stand-alone tool that can be used with any model.   Day 5 – Automating Simulations in R using lixoftConnectors Building and running Simulx projects in R. Visualizing the results. Creating forest plots. You’ll gain practical experience in scripting to automate simulations, making large scale pharmacometrics simulations more efficient.   Weather you’re new to simulations or looking to refine your approach, this course is a great opportunity to gain practical expertise in Simulx and discover how simulations can enhance your pharmacometrics analysis and decision-making.      Frequently Asked Questions I've never used Monolix or Simulx, can I attend the course? Yes, everyone can join. Knowledge of Monolix or Simulx is not mandatory. The course with start from a beginner level. Do I need to install MonolixSuite on my computer? You can follow lectures without installing MonolixSuite, but you will need it to complete the hands-ons.  Do I have to pay for the MonolixSuite licence? We offer a free temporary licence for this course valid from March 17 to April 12, 2025. If you are academic, or working in a non-profit organization, you can request a free licence. See our website: link. Read more

PAGE 2025 Conference Satellite Workshop Advanced Course for Pharmacometrics Modeling and Automatisation using MonolixSuiteTM 2 days: Monday-Tuesday 2-3 June 2025: 9AM – 5PM This is an IN-PERSON WORKSHOP taking place in Thessaloniki, Greece, as a satellite event of the PAGE conference. Take your modeling and simulation skills to the next level: gain insights into the methods and algorithms behind each task and the impact of their settings; learn how to write and diagnose intricate models effectively such as non-standard parameter-covariate relationships or non-continuous data; improve your approach to covariate model building and inter-occasion variability for enhanced outcomes. automatise modeling and simulation workflows by scripting in R using lixoftConnectors. This course is composed of two course: 1. “Advanced Course for Pharmacometrics Modeling using Monolix“ - 1.5 days 2. “Automating Pharmacometrics Modeling and Simulations: Scripting using lixoftConnectors“ - 0.5 days Includes practical, hands-on exercises. No prior experience with MonolixSuite is necessary. Includes a temporary licence for the MonolixSuite. Price per person The prices are VAT exempted, it will be added if applicable. Industry: 1000€ – Academia: 500€  (total price for two workshops) Payment Method: Credit Card*  *If you are unable to complete payment with a credit card please contact education@simulations-plus.com to request and invoice to pay via direct wire transfer. Location This is an in-person workshop in Thessaloniki, Greece. Venue of the workshop will be communicated later (Thessaloniki Concert Hall - conference venue, or nearby). Read more

PAGE 2025 Conference Satellite Workshop Introductory Course for Pharmacometrics Modeling and Automatisation using MonolixSuiteTM 2 days: Monday-Tuesday 2-3 June 2025: 9AM – 5PM This is an IN-PERSON WORKSHOP taking place in Thessaloniki, Greece, as a satellite event of the PAGE conference. Whether you’re a novice in population modeling eager to start working on your PK and PK-PD projects, or an intermediate modeler aiming to boost your confidence and make strategic decisions. Gain essential skills to develop, diagnose and interpret models and discover the potential of workflow automation by scripting workflows using lixoftConnectors. This course is composed of two course: 1. “Introductory course for pharmacometrics modeling using Monolix“ - 1.5 days 2. “Automating Pharmacometrics Modeling and Simulations: Scripting using lixoftConnectors“ - 0.5 days Includes practical, hands-on exercises. No prior experience with MonolixSuite is necessary. Includes a temporary licence for the MonolixSuite. Price per person The prices are VAT exempted, it will be added if applicable. Industry: 1000€ – Academia: 500€  (total price for two workshops) Payment Method: Credit Card*  *If you are unable to complete payment with a credit card please contact education@simulations-plus.com to request and invoice to pay via direct wire transfer. Location This is an in-person workshop in Thessaloniki, Greece. Venue of the workshop will be communicated later (Thessaloniki Concert Hall - conference venue, or nearby). Read more

PAGE 2025 Conference Satellite Workshop Advanced Course for Pharmacometrics Modeling and Simulations using MonolixSuiteTM 2 days: Monday-Tuesday 2-3 June 2025: 9AM – 5PM This is an IN-PERSON WORKSHOP taking place in Thessaloniki, Greece, as a satellite event of the PAGE conference. Take your modeling and simulation skills to the next level: gain insights into the methods and algorithms behind each task and the impact of their settings; learn how to write and diagnose intricate models effectively such as non-standard parameter-covariate relationships or non-continuous data; improve your approach to covariate model building and inter-occasion variability for enhanced outcomes. set up simulation scenarios to efficiently answer “what if” questions. This course is composed of two course: 1. “Advanced course for pharmacometrics modeling using Monolix“ - 1.5 days 2. “From simple to complex simulations in pharmacometrics using Simulx“ - 0.5 days Includes practical, hands-on exercises. No prior experience with MonolixSuite is necessary. Includes a temporary licence for the MonolixSuite. Price per person The prices are VAT exempted, it will be added if applicable. Industry: 1000€ – Academia: 500€  (total price for two workshops) Payment Method: Credit Card*  *If you are unable to complete payment with a credit card please contact education@simulations-plus.com to request and invoice to pay via direct wire transfer. Location This is an in-person workshop in Thessaloniki, Greece. Venue of the workshop will be communicated later (Thessaloniki Concert Hall - conference venue, or nearby). Read more

PAGE 2025 Conference Satellite Workshop Introductory Course for Pharmacometrics Modeling and Simulations using MonolixSuiteTM 2 days: Monday-Tuesday 2-3 June 2025: 9AM – 5PM This is an IN-PERSON WORKSHOP taking place in Thessaloniki, Greece, as a satellite event of the PAGE conference. Whether you’re a novice in population modeling eager to start working on your PK and PK-PD projects, or an intermediate modeler aiming to boost your confidence and make strategic decisions. Gain essential skills to develop, diagnose and interpret models, and efficiently use algorithms within Monolix and set up simulation scenarios to efficiently answer “what if” questions. This course is composed of two course: 1. “Introductory course for pharmacometrics modeling using Monolix“ - 1.5 days 2. “From simple to complex simulations in pharmacometrics using Simulx“ - 0.5 days Includes practical, hands-on exercises. No prior experience with MonolixSuite is necessary. Includes a temporary licence for the MonolixSuite. Price per person The prices are VAT exempted, it will be added if applicable. Industry: 1000€ – Academia: 500€  (total price for two workshops) Payment Method: Credit Card*  *If you are unable to complete payment with a credit card please contact education@simulations-plus.com to request and invoice to pay via direct wire transfer. Location This is an in-person workshop in Thessaloniki, Greece. Venue of the workshop will be communicated later (Thessaloniki Concert Hall - conference venue, or nearby). Read more

PAGE 2025 Conference Satellite Workshop Automating Pharmacometrics Modeling and Simulations: scripting using lixoftConnectorsTM 0.5 day: Tuesday 3rd June 2025: 13 AM – 5 PM This is an IN-PERSON WORKSHOP taking place in Thessaloniki, Greece, as a satellite event of the PAGE conference. Discover the potential of workflow automation in pharmacometrics modeling and simulations with our half-day course on using lixoftConnectors. These R-API functions offer direct access to MonolixSuite applications from within R and enable you to seamlessly script complex workflows and revolutionize your approach to phamacometrics. What you will discover: R-API functions: gain insight into the applications of lixoftConnectors to access MonolixSuite from R. Workflow automation: understand the fundamental principles of these functions and how to script modeling and simulation tasks efficiently. Integration of MonolixSuite: learn about benefits from the direct connectivity between R and MonolixSuite through lixoftConnects. This course is designed for professionals with at least basic knowledge about Monolix and Simulx, who seek to script their pharmacometrics workflows. It features both lectures and interactive hands-on sessions. Join us to unlock the potential of lixoftConnectors to elevate your pharmacometrics projects. Includes a temporary licence for the MonolixSuite. More courses at PAGE Combine this course with one of the 1.5 day workshops on Monday 2nd June 2024: 9AM – 5PM and Tuesday 3rd June 2025: 9AM – 12PM: “Introductory course for pharmacometrics modeling using Monolix“ “Advanced course for pharmacometrics modeling using Monolix“ Price per person The prices are VAT exempted, it will be added if applicable. Automatic pharmacometrics modeling and simulations: scripting using lixoftConnectors: Industry: 400€ – Academia: 200€  (total price for one workshop) Automatic pharmacometrics modeling and simulations: scripting using lixoftConnectors + second 1.5 day workshop June 2-3rd: Get a 50% discount on this second workshop if you register to two! Industry: 1000€ – Academia: 500€  (total price for two workshops) Lunch and coffee breaks on Monday and Tuesday are included. Payment Method: Credit Card*  *If you are unable to complete payment with a credit card please contact education@simulations-plus.com to request and invoice to pay via direct wire transfer. Location This is an in-person workshop in Thessaloniki, Greece - Thessaloniki Concert Hall Read more