November 2nd - 6th, 2026 (Virtual) - At the completion of the workshop you will have an understanding of the inputs and interactions that exist among the various mechanistic phenomena affecting drug dissolution, absorption, distribution, metabolism and elimination. You will be able to use GastroPlus to generate robust PBPK models integrating compound properties, data and mechanisms and to apply them to scenarios involving special populations and Drug Drug Interactions. PBPK Autumn School: From Basics to Practical Application with GastroPlus® 2026 Introduce the essential concepts for building PBPK models and explore the primary FDA-labeled applications of PBPK modeling. Free Online Training | November 2 - 6, 2026 Note: Even though his year’s course covers the same core topics as last year, we encourage you to attend again! With the experience you have gained this last year, you’ll be ready to dive in with confidence, and you might pick up ideas and skills you didn’t see before. Whether you’re revisiting familiar ground or exploring new angles, this is a chance to deepen your understanding and take your learning to the next level! Why This Training Matters The GastroPlus Autumn School is designed for modelers who wish to learn the basics of PBPK modeling and apply their newly learned skills to take their modeling further and faster using GastroPlus. Over five intensive sessions you'll learn how to estimate the distribution and elimination of an API following intravenous administration, setup basic parameters influencing absorption, and use your validated PBPK model to extrapolate the pharmacokinetics of an API in special populations and to predict Drug-Drug interactions. More than a software tutorial, this course gives you the framework, skills and mindset to support First-in-Human applications, and additional Clinical Pharmacology regulatory decisions.  You'll see not only "how" to use novel GastroPlus features but "why" they must be utilized in a certain order, to support your PBPK model endeavor. With hands-on exercises, live expert guidance, and a free temporary GastroPlus license, you'll be able to experiment directly on your own projects and bring back immediately usable workflows to your team. How You Will Learn Five Live online lectures led by GastroPlus experts Learn directly from the people who develop and use the tools at the highest level, gaining not just instructions but insight into best practices, strategies, and real-world applications. Two identical 2 h sessions per day - choose the time zone that fits you - sessions are recorded: Ensure you can participate live, ask questions, and learn at your best time without missing content or interaction. Interactive Q&A chat during each session with GastroPlus experts: Get immediate answers to your modeling challenges and clarify concepts as you learn, turning lectures into active problem-solving sessions. Hands-on exercises to reinforce new skills: Apply what you've just learned in a guided environment, moving from theory to practice and cementing your ability to replicate these workflows later. Comprehensive materials: presentations, datasets, and GastroPlus projects: Build your own reference library to revisit concepts, test workflows on your own time, and accelerate mastery after the course. Certificate of attendance: Demonstrate your training in advanced PBPK and GastroPlus to colleagues, supervisors, or regulatory bodies. Free temporary license for GastroPlus: Use the same tools you're learning on your own projects, experiment with advanced features, and get immediate help from experts during the course - turning learning into direct project impact. Agenda: Session 1: Practical Guide to Define API Distribution Using PBPK Models Session 2: Clearance IVIVE Using PBPK Models Session 3: Practical PBPK Considerations for Oral Models Session 4: PBPK Models for Special Populations Session 5: PBPK Models for Drug Drug Interactions Read more

On Demand - This training will provide a roadmap for the use of outputs from the DILIsym® module in ADMET Predictor® to derive an early assessment of hepatotoxic risk within the DILIsym Quantitative Systems Toxicology (QST) software. Learn a workflow permissive for early discovery applications! Instructed by Lisl Shoda, Vice President QSP; James Beaudoin, Principal Scientist; and Christina Battista, Senior Principal Scientist.  ADMET Predictor® DILIsym® Module Outputs to Assess Liver Toxicity Rankings On-Demand | Introductory | Learn at your own Pace Description: Learn how to efficiently assess and rank the hepatotoxicity risk of drug candidates early in development using the ADMET Predictor 12 DILIsym module in this hands-on training. Discover how to leverage machine learning-based predictions from compound structure, generate key toxicity parameters, and simulate in vivo liver injury scenarios with minimal data. The course covers step-by-step workflows, practical examples, and best practices for parameterizing and interpreting DILIsym outputs, enabling rapid, cost-effective liver safety evaluations across all stages of drug discovery Who should take this training: This training is ideal for scientists working in drug discovery and development—such as toxicologists, pharmacologists, and computational chemists—who need to evaluate liver safety risks of new compounds. It is especially valuable for those in early-stage research or preclinical roles, regardless of experience level, who want to streamline toxicity assessments using predictive modeling and minimal experimental data. Attendees will gain practical skills to make informed, structure-based decisions and accelerate compound progression with confidence. Registration Details: This course is on-demand; register anytime!  Access Duration: 1 year from the date you enroll Pricing Information: Commercial/Industry: $50 Academic/Government/Non-profit/Regulatory/SLP-TAP: $25* *To receive membership pricing, you must use an affiliated email address with a qualifying institution. Personal email accounts (Gmail, Yahoo, etc.) are automatically disqualified. If you need to change your email address or inquire about membership pricing please email education@simulations-plus.com Agenda: Introduction to ADMET Predictor 12 DILIsym module and Quantitative Systems Toxicology Overview of hepatotoxicity mechanisms and early-stage risk assessment Step-by-step workflow for using ADMET Predictor outputs in DILIsym Importing and preparing compound structure files (SMILES, SDF) Generating and interpreting toxicity mechanism classifications and parameter estimates Parameterizing DILIsym simulations with APD module outputs Setting up and running DILIsym simulations for liver toxicity prediction Normalizing and comparing liver exposure across compounds Interpreting simulation results and ranking hepatotoxicity risk Practical examples and case studies Best practices, troubleshooting Certification A certificate is available upon completion of this course with a passing score on the learning checks. Certificates will arrive via email from our training portal. Please make sure you can receive messages from slp.edu@simulations-plus.com. (Note: this email's inbox is not monitored, and you will not receive a reply.) Software Requirements ADMET Predictor and DILIsym access is recommended. A complimentary 30-day evaluation is available upon purchase of this course. After purchase, contact sales@simulations-plus.com and attach receipt of purchase to request an evaluation. Read more

October 10th, 2026 (In Person) - ACoP 2026 Satellite Workshop: Accelerate your QSP modeling with agentic AI in Thales. Use natural language to explore models, simulate virtual populations, optimize results, and analyze outcomes; all through S+ Composer. Gain hands-on experience applying AI-driven workflows to real-world model-informed drug development challenges. Designed for scientists and modelers who want to compress the cycle from question to insight. Acceleration of Clinical Trial Modeling with Agentic AI using the Thales QSP Software Platform ACoP 2026 Pre-Conference Workshop - In Person Date: October 10th, 2026 Time: 8am - 5pm Eastern Location: ACoP 2026 Conference: Gaylord National Resort & Convention Center, National Harbor, MD Course Description: This workshop provides a tutorial for engagement of Thales (a cloud-based QSP modeling platform) through a new chat-based interface for S+ software packages referred to as the “S+ Composer platform”.   We will introduce new agentic AI tools that accelerate end-to-end modeling workflows for QSP through S+ Composer. The 1-day session combines lectures with practical exercises to build fluency with AI-driven QSP modeling in translational and clinical modeling contexts.  The initial content of the workshop will provide a brief description of Thales but will focus primarily on its engagement via agents specially designed to facilitate QSP modeling.  We will be discussing how to prompt agents for a variety of different goals, including model interrogation and exploration, addition of biological components, virtual population simulation & optimization, and analysis of results.    Practical sessions to follow in the next part of the workshop will allow participants to engage in prompting and exploration of QSP modeling tools using agentic AI, using case-based examples relevant to current needs in model-informed drug development. Users will gain first-hand experience in developing, exploring and evaluating models supported by AI, along with other common modeling workflows.  Towards the end of the workshop, we will dive deeper into practical use of the agents towards specific QSP applications.  Emphasis will be placed on engaging with the Thales platform’s native support of virtual populations, ability to simultaneously optimize data spanning numerous therapeutic interventions, and utility in supporting late-phase clinical decision-making.  There will also be a discussion on how to use multiple agents in concert to support MIDD workflows that span the drug development spectrum within S+ Composer.  The workshop is designed for modelers and scientists with pharmacometrics or QSP experience who want to evaluate how agentic AI can compress the iteration cycle for virtual clinical trial simulation.  Pricing: Early Bird price (on or before September 1) = Commercial $500 | Academic or Government $250 | SLP-TAP $200 (limited seat availability) Standard price (after September 1) = Commercial $750 | Academic or Government $375 | SLP-TAP $200 (limited seat availability) Registration for this workshop Closes Tuesday September 22nd at 5:00 PM Eastern Time. FAQs and Cancellation Policy Read more

October 25th, 2026 (In-person, AAPS PharmSci 360) - This introductory educational meeting provides participants with a practical introduction to state-of-the-art PBBM and PBPK modeling workflows in GastroPlus®. Designed for academic and industry scientists, the course combines scientific principles, real-world applications, and hands-on demonstrations. Participants will learn how to apply PBBM approaches for oral drug products, including P-PSD modeling, IVIVC, and VBE. The course also examines PBPK modeling in pediatric and other special populations, demonstrating how the GastroPlus API can automate simulations, evaluate drug exposure across subgroups, and support efficient report generation. Prior experience with GastroPlus is helpful but not required. The course is suitable for participants seeking a practical understanding of modern PBBM-PBPK workflows and their automation. GastroPlus® PBBM–PBPK Modeling: Oral Drug Product Workflows, Subpopulation Analysis, and API-Driven Automation We’re excited to present to you this intensive 1/2-day educational session designed to show you how to extend and accelerate your PBBM–PBPK workflows using the GastroPlus® application programming interface (API) in R.  We look forward to learning with you and helping you build the skills to handle complex models, and turn data into actionable insights for drug development.  — GastroPlus Team at Simulations Plus  Course Dates and Access  Live, In person satellite session to AAPS PharmSci360 Conference.  Date: October 25th, 2026  Time: 12:00 PM to 4:00 PM Central Time Location: Riverside Room (1st Floor) at the New Orleans Ernest N Memorial Convention Center (900 Convention Center   Blvd, New Orleans, LA 70130). Access to the content in this course is available until: November 22nd, 2026 (inclusive) this date cannot be extended.  Agenda There will be 2 sessions during this educational meeting. Session 1: ~12pm-2pm The first session focuses on PBBM for oral drug products, including how to initiate a modeling project and apply advanced workflows for formulation development and regulatory decision-making. Key topics include mechanistic particle-size distribution (P-PSD) modeling, in vitro–in vivo correlations (IVIVC), and virtual bioequivalence (VBE). Session 2: ~2pm-4pm The second session explores PBPK modeling in special populations, with a particular focus on pediatric populations. Participants will learn how the GastroPlus API can automate simulations across age groups, identify subpopulations at increased risk of altered drug exposure, and generate standardized reports. The session will also discuss how these automated workflows can be extended to other special populations. Software Requirements  If you plan to work with GastroPlus during or after the sessions, install it in advance.   A complimentary 14-day GastroPlus license is provided Installation and license information is provided after registration. Instructors will use GastroPlus X.2, R Base, R Studio and R tools during the course.   ​University students and educators may be eligible for free access to Simulations Plus software through the University+ Program. This program provides one‑year access to industry‑leading modeling and simulation tools for accredited universities worldwide, supporting hands‑on learning and skill development in PBPK modeling, pharmacometrics and model informed drug development (MIDD). Please note: Application processing time is currently running 2-3 weeks. We recommend using the temporary installation provided in module 2 while you wait for your application to process. Certificates   Certificate of Completion available by e-mail if you meet all course requirements. Please allow 3-5 days after completing the requirements for certificate processing. Q&A Support & Tips for a Successful Experience Technical support questions – email support@simulations-plus.com Educational support questions - email education@simulations-plus.com Tips for Successful Experience  Download the software and R programs in advance so if you run into any trouble, you have time to ask questions.   Download the materials before the session so you're ready to follow along.   Make sure your computer has a full charge. Arrive 10 minutes early to get settled in your seat.   FAQs and Cancellation Policy Read more

October 10-11, 2026 (In Person) -  MONOLIXSUITE ACoP 2026 SATELLITE WORKSHOPS A two-day, hands-on workshop covering the complete population PK-PD modeling and simulation workflow in MonolixSuite: from dataset exploration to clinical trial simulation. You'll build both software fluency and the scientific judgment to work critically in the age of AI, including an introduction to MonolixSuite's AI-assisted modeling tools.   From PK-PD Models to Simulations using MonolixSuiteTM :  Modeling in the Age of AI ACoP 2026 Satellite Workshop     Dates: Oct 10th-11th (Saturday and Sunday), 8AM - 5 PM  Venue: Gaylord National Resort and Convention Center, National Harbor, Maryland Course description AI agents can already handle parts of the modeling workflow that once took hours by hand: writing Mlxtran code, running PK workflows, generating diagnostics. That shift makes one skill more valuable than ever — the scientific judgment to know whether the output is right. This two-day workshop is built around that idea. You will work through a complete population PK-PD modeling and simulation workflow in MonolixSuite, combining lectures and hands-on exercises to build both fluency with the software and the deeper understanding that lets you work critically, whether you are using the interface yourself or supervising an AI agent. Part 1: Modeling We cover the full modeling workflow. You will explore a dataset, build structural and statistical models, run a covariate search, and develop a PK-PD model. Alongside the practical work, we make time for concepts often skipped: what the estimation algorithms are actually doing, and how to read diagnostic plots with real understanding. Part 2: Simulations We start with the question and then the practical skills to build simulations: which types of simulation you can run, which sources of uncertainty to include and why, and how to analyse the results, including testing differences statistically rather than by eye. Part 3: AI Agents We open the black box: what a large language model (LLM) is, how to build an agent, and how prompting, context and tool access shape what an AI system produces. From there we look at what makes a good modeling agent, how to actually do modeling with one, and where your judgement and review stay essential. This workshop does not start from zero. You should be able to run a basic PK workflow in Monolix: load a dataset, set up a model, run an estimation. If you are not there yet, we offer a free preparatory course covering the essentials so you arrive ready to benefit fully from both days.  Includes a temporary license for the MonolixSuite.   Questions? Ask support@simulations-plus.com   Pricing   Early bird before Sept 1 Standard Industry $775 $995 Academic 50% off $387.50 $497.50 Prices are per person and VAT-exempt; VAT will be added where applicable. Payment Payment is by credit card. If you can't pay by card, email education@simulations-plus.com to request an invoice and pay by direct wire transfer. Registration for this workshop Closes Tuesday September 22nd at 5:00 PM Eastern Time. Location This is an IN-PERSON WORKSHOP taking place in Gaylord National Resort and Convention Center, National Harbour, Maryland as a satellite event of the ACoP2026 Conference.  FAQs and Cancellation Policy Read more

On Demand - This hands-on training course will introduce participants to the basic use and new features of RENAsym® v2A, for both new and experienced users. Guided exercises will walk users through the usage of RENAsym to predict drug-induced kidney injury, and users will also be introduced to improvements made for RENAsym v2A. Attendees can request a complimentary, 2-week trial of RENAsym®. Please fill out a request form located here. Read more