November 2nd - 6th, 2026 (Virtual) - At the completion of the workshop you will have an understanding of the inputs and interactions that exist among the various mechanistic phenomena affecting drug dissolution, absorption, distribution, metabolism and elimination. You will be able to use GastroPlus to generate robust PBPK models integrating compound properties, data and mechanisms and to apply them to scenarios involving special populations and Drug Drug Interactions. PBPK Autumn School: From Basics to Practical Application with GastroPlus® 2026 Introduce the essential concepts for building PBPK models and explore the primary FDA-labeled applications of PBPK modeling. Free Online Training | November 2 - 6, 2026 Note: Even though his year’s course covers the same core topics as last year, we encourage you to attend again! With the experience you have gained this last year, you’ll be ready to dive in with confidence, and you might pick up ideas and skills you didn’t see before. Whether you’re revisiting familiar ground or exploring new angles, this is a chance to deepen your understanding and take your learning to the next level! Why This Training Matters The GastroPlus Autumn School is designed for modelers who wish to learn the basics of PBPK modeling and apply their newly learned skills to take their modeling further and faster using GastroPlus. Over five intensive sessions you'll learn how to estimate the distribution and elimination of an API following intravenous administration, setup basic parameters influencing absorption, and use your validated PBPK model to extrapolate the pharmacokinetics of an API in special populations and to predict Drug-Drug interactions. More than a software tutorial, this course gives you the framework, skills and mindset to support First-in-Human applications, and additional Clinical Pharmacology regulatory decisions.  You'll see not only "how" to use novel GastroPlus features but "why" they must be utilized in a certain order, to support your PBPK model endeavor. With hands-on exercises, live expert guidance, and a free temporary GastroPlus license, you'll be able to experiment directly on your own projects and bring back immediately usable workflows to your team. How You Will Learn Five Live online lectures led by GastroPlus experts Learn directly from the people who develop and use the tools at the highest level, gaining not just instructions but insight into best practices, strategies, and real-world applications. Two identical 2 h sessions per day - choose the time zone that fits you - sessions are recorded: Ensure you can participate live, ask questions, and learn at your best time without missing content or interaction. Interactive Q&A chat during each session with GastroPlus experts: Get immediate answers to your modeling challenges and clarify concepts as you learn, turning lectures into active problem-solving sessions. Hands-on exercises to reinforce new skills: Apply what you've just learned in a guided environment, moving from theory to practice and cementing your ability to replicate these workflows later. Comprehensive materials: presentations, datasets, and GastroPlus projects: Build your own reference library to revisit concepts, test workflows on your own time, and accelerate mastery after the course. Certificate of attendance: Demonstrate your training in advanced PBPK and GastroPlus to colleagues, supervisors, or regulatory bodies. Free temporary license for GastroPlus: Use the same tools you're learning on your own projects, experiment with advanced features, and get immediate help from experts during the course - turning learning into direct project impact. Agenda: Session 1: Practical Guide to Define API Distribution Using PBPK Models Session 2: Clearance IVIVE Using PBPK Models Session 3: Practical PBPK Considerations for Oral Models Session 4: PBPK Models for Special Populations Session 5: PBPK Models for Drug Drug Interactions Read more

On Demand - This training will provide a roadmap for the use of outputs from the DILIsym® module in ADMET Predictor® to derive an early assessment of hepatotoxic risk within the DILIsym Quantitative Systems Toxicology (QST) software. Learn a workflow permissive for early discovery applications! Instructed by Lisl Shoda, Vice President QSP; James Beaudoin, Principal Scientist; and Christina Battista, Senior Principal Scientist.  ADMET Predictor® DILIsym® Module Outputs to Assess Liver Toxicity Rankings On-Demand | Introductory | Learn at your own Pace Description: Learn how to efficiently assess and rank the hepatotoxicity risk of drug candidates early in development using the ADMET Predictor 12 DILIsym module in this hands-on training. Discover how to leverage machine learning-based predictions from compound structure, generate key toxicity parameters, and simulate in vivo liver injury scenarios with minimal data. The course covers step-by-step workflows, practical examples, and best practices for parameterizing and interpreting DILIsym outputs, enabling rapid, cost-effective liver safety evaluations across all stages of drug discovery Who should take this training: This training is ideal for scientists working in drug discovery and development—such as toxicologists, pharmacologists, and computational chemists—who need to evaluate liver safety risks of new compounds. It is especially valuable for those in early-stage research or preclinical roles, regardless of experience level, who want to streamline toxicity assessments using predictive modeling and minimal experimental data. Attendees will gain practical skills to make informed, structure-based decisions and accelerate compound progression with confidence. Registration Details: This course is on-demand; register anytime!  Access Duration: 1 year from the date you enroll Pricing Information: Commercial/Industry: $50 Academic/Government/Non-profit/Regulatory/SLP-TAP: $25* *To receive membership pricing, you must use an affiliated email address with a qualifying institution. Personal email accounts (Gmail, Yahoo, etc.) are automatically disqualified. If you need to change your email address or inquire about membership pricing please email education@simulations-plus.com Agenda: Introduction to ADMET Predictor 12 DILIsym module and Quantitative Systems Toxicology Overview of hepatotoxicity mechanisms and early-stage risk assessment Step-by-step workflow for using ADMET Predictor outputs in DILIsym Importing and preparing compound structure files (SMILES, SDF) Generating and interpreting toxicity mechanism classifications and parameter estimates Parameterizing DILIsym simulations with APD module outputs Setting up and running DILIsym simulations for liver toxicity prediction Normalizing and comparing liver exposure across compounds Interpreting simulation results and ranking hepatotoxicity risk Practical examples and case studies Best practices, troubleshooting Certification A certificate is available upon completion of this course with a passing score on the learning checks. Certificates will arrive via email from our training portal. Please make sure you can receive messages from slp.edu@simulations-plus.com. (Note: this email's inbox is not monitored, and you will not receive a reply.) Software Requirements ADMET Predictor and DILIsym access is recommended. A complimentary 30-day evaluation is available upon purchase of this course. After purchase, contact sales@simulations-plus.com and attach receipt of purchase to request an evaluation. Read more

October 25th, 2026 (In-person, AAPS PharmSci 360) - This introductory educational meeting provides participants with a practical introduction to state-of-the-art PBBM and PBPK modeling workflows in GastroPlus®. Designed for academic and industry scientists, the course combines scientific principles, real-world applications, and hands-on demonstrations. Participants will learn how to apply PBBM approaches for oral drug products, including P-PSD modeling, IVIVC, and VBE. The course also examines PBPK modeling in pediatric and other special populations, demonstrating how the GastroPlus API can automate simulations, evaluate drug exposure across subgroups, and support efficient report generation. Prior experience with GastroPlus is helpful but not required. The course is suitable for participants seeking a practical understanding of modern PBBM-PBPK workflows and their automation. GastroPlus® PBBM–PBPK Modeling: Oral Drug Product Workflows, Subpopulation Analysis, and API-Driven Automation We’re excited to present to you this intensive 1/2-day educational session designed to show you how to extend and accelerate your PBBM–PBPK workflows using the GastroPlus® application programming interface (API) in R.  We look forward to learning with you and helping you build the skills to handle complex models, and turn data into actionable insights for drug development.  — GastroPlus Team at Simulations Plus  Course Dates and Access  Live, In person satellite session to AAPS PharmSci360 Conference.  Date: October 25th, 2026  Time: 12:00 PM to 4:00 PM Central Time Location: Riverside Room (1st Floor) at the New Orleans Ernest N Memorial Convention Center (900 Convention Center   Blvd, New Orleans, LA 70130). Access to the content in this course is available until: November 22nd, 2026 (inclusive) this date cannot be extended.  Agenda There will be 2 sessions during this educational meeting. Session 1: ~12pm-2pm The first session focuses on PBBM for oral drug products, including how to initiate a modeling project and apply advanced workflows for formulation development and regulatory decision-making. Key topics include mechanistic particle-size distribution (P-PSD) modeling, in vitro–in vivo correlations (IVIVC), and virtual bioequivalence (VBE). Session 2: ~2pm-4pm The second session explores PBPK modeling in special populations, with a particular focus on pediatric populations. Participants will learn how the GastroPlus API can automate simulations across age groups, identify subpopulations at increased risk of altered drug exposure, and generate standardized reports. The session will also discuss how these automated workflows can be extended to other special populations. Software Requirements  If you plan to work with GastroPlus during or after the sessions, install it in advance.   A complimentary 14-day GastroPlus license is provided Installation and license information is provided after registration. Instructors will use GastroPlus X.2, R Base, R Studio and R tools during the course.   ​University students and educators may be eligible for free access to Simulations Plus software through the University+ Program. This program provides one‑year access to industry‑leading modeling and simulation tools for accredited universities worldwide, supporting hands‑on learning and skill development in PBPK modeling, pharmacometrics and model informed drug development (MIDD). Please note: Application processing time is currently running 2-3 weeks. We recommend using the temporary installation provided in module 2 while you wait for your application to process. Certificates   Certificate of Completion available by e-mail if you meet all course requirements. Please allow 3-5 days after completing the requirements for certificate processing. Q&A Support & Tips for a Successful Experience Technical support questions – email support@simulations-plus.com Educational support questions - email education@simulations-plus.com Tips for Successful Experience  Download the software and R programs in advance so if you run into any trouble, you have time to ask questions.   Download the materials before the session so you're ready to follow along.   Make sure your computer has a full charge. Arrive 10 minutes early to get settled in your seat.   FAQs and Cancellation Policy Read more

On Demand - This hands-on training course will introduce participants to the basic use and new features of RENAsym® v2A, for both new and experienced users. Guided exercises will walk users through the usage of RENAsym to predict drug-induced kidney injury, and users will also be introduced to improvements made for RENAsym v2A. Attendees can request a complimentary, 2-week trial of RENAsym®. Please fill out a request form located here. Read more

On Demand - This hands-on training course introduces participants to the latest features and sub-models in DILIsym® version 11, designed to support both new and experienced users. Through guided exercises, attendees will gain practical experience navigating enhancements in mechanistic modeling of drug-induced liver injury. While prior completion of the 2023 DILIsym Crash Course is recommended for foundational context, it is not required to participate. Attendees can request a complimentary 2-week trial of DILIsym. Please fill out a request form located here. Read more

On-Demand | GPX™ Tutorial Series I gives you the practical know-how to use GastroPlus® X effectively. Learn the essential steps to set up, run, and interpret simulations—all in clear, easy-to-follow videos. No fluff, just the tools and techniques you need to get results quickly. Perfect for professionals who want speed, simplicity, and confidence. Now available in Chinese, French, Japanese, Korean, Portuguese and Spanish languages. Register for more information! GastroPlus X Tutorial Series I 1. The GPX™ Paradigm 2. GPX™ Legacy Import 3. Creating a project from Scratch in GPX 4. Dosing Schedules 5. Physiologies and Physiology Schedules 6. ADMET Predictor® Import 7. Compound Forms and Solubility 8. GPX™ Run Modes --Simulation & Optimization --PSA --Pop Sim and VBE 9. Asset Export Import 10. Simplified Absorption and PK 11. Reporting Outputs 12. Lab Book 13. Recreating a Project in Legacy GastroPlus® Read more